The complexity of cellular networks

8. Modeling the full cellular
regulatory system 1

  OUTLINE

• Gap between genes and phenotypes in molecular biology
• Can we define biological function based on the system’s dynamics?
• A minimal model of the global regulatory system as an ordered dynamical system
• Function as an attractor state of the regulatory system
  • Homeostasis, multi-stability and choice of function
  • Epigenetics and the role of microenvironment
  • Disease in the conceptual framework of dynamical attractors
• The attractors of cancer and metastasis (example)

 Lecture 8 

DEFINITIONS

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