The complexity of cellular networks

4. Cellular noise (cont.)
The logic of genetic regulation

  OUTLINE

• Noise in the cell
  • Extrinsic and intrinsic noise
  • Transcriptional and translational contributions
  • Phenotypic consequences of cellular noise
• The Logic of Genetic Regulation
  • Thermodynamics of Boolean logic gates driving non-linear expression
  • Experimental measurement of transcriptional logic in e. Coli
  • Network motifs and their regulatory functions
    • The feed-forward loop
    • Temporal ordering

 Lecture 4 (pdf) 

DEFINITIONS

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