: 3:00 - 3:40 PM
Type: Invited presentation
Affiliation: CNRS, Université de Lille Sciences et Technologies
Cellular regulatory networks often exhibit a sophisticated architecture made
of many interlocked feedback loops operating at multiple timescales, even in
the case of an a priori simple cellular function: a differentiation decision switch.
In this presentation, I wish to discuss the notion that the complex design of
differentiation regulatory network reflects various requirements, most likely
related to the fact that the differentiation process competes or cooperates with
other cellular processes (e.g.,alternative differentiation fates, proliferation,
metabolism, cell-cell communication etc...). This discussion will draw upon recent
theoretical studies based on abstract and detailed network models, with special
emphasis on the issue of how the differentiation process is intimately linked to
the cell-cycle and intercellular signaling processes.