Design principles of differentiation regulatory networks

Benjamin Pfeuty

Time: 3:00 - 3:40 PM

Type: Invited presentation

Affiliation: CNRS, Université de Lille Sciences et Technologies

Abstract

Cellular regulatory networks often exhibit a sophisticated architecture made of many interlocked feedback loops operating at multiple timescales, even in the case of an a priori simple cellular function: a differentiation decision switch. In this presentation, I wish to discuss the notion that the complex design of differentiation regulatory network reflects various requirements, most likely related to the fact that the differentiation process competes or cooperates with other cellular processes (e.g.,alternative differentiation fates, proliferation, metabolism, cell-cell communication etc...). This discussion will draw upon recent theoretical studies based on abstract and detailed network models, with special emphasis on the issue of how the differentiation process is intimately linked to the cell-cycle and intercellular signaling processes.