: 9:10 - 10:00 AM
Type: Invited presentation
Affiliation: Niels Bohr Institute, University of Copenhagen
Cells can be in different states maintained dynamically
by positive feedback mechanisms. A subset of these dynamic
systems are formed by histones recruiting "read-write"
enzymes which in turn modify other histones.
This opens for a level of local genetic regulation working on
We explore simple examples of such histone codes,
and use tools from theoretical physics
to pinpoint the minimal requirements for histone
The developed models inspire new perspectives on
a variety of developmental systems,
including in particular the differentiation of olfactoric
neuronal cells. A system where one and only one of
1000 genes are expressed in each cell.