: 11:00 - 11:50 AM
Type: Invited presentation
Affiliation: Faculty of Life Sciences, University of Manchester, UK
The Nuclear Factor kappaB (NF-kappaB) transcription factor is a key driver of
inflammation and immune response to pathogens. In response to infection and cytokine
stimulation, the system exhibits complex and noisy dynamics generated via the set
of negative and positive regulatory feedback loops that control patterns of
downstream gene expression. Using multidisciplinary systems biology approach
we aim to resolve design principles behind NF-kappaB circuit, its dynamics and function.
A new quantitative understanding of this complex and nonlinear network will move
us towards better therapeutic strategies for inflammatory disease.