The complexity of cellular networks

9. Modeling the full cellular
regulatory system 2

  OUTLINE

• Gap between the elegance of the dynamical system framework and its use in molecular biology
• Experimental evidence of modular, hierarchical organization
• Dynamical autonomy of biological modules
  • Homeostasis and multistability in a modular system
  • Functional annotation revisited
• Dynamical relationships at the level of regulatory modules
  • Signaling and the role of microenvironment
• A hierarchy of regulatory modules
  • Cellular heterogeneity and disease in a modular hierarchy

 Lecture 9 

DEFINITIONS

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